Who we are

Custom Reference Standards. Global Impact.

TLC specializes in the custom synthesis of complex organic compounds used as pharmaceutical reference standards worldwide. Our materials support high-confidence analytical testing, regulatory submissions, and drug development across the global life sciences industry.

About TLC

Quality & Compliance

Uncompromised Quality

Quality is ingrained in everything we do. Every reference standard is supplied with a comprehensive Certificate of Analysis (COA) and fully characterized using advanced analytical techniques, including HPLC, NMR, MS, IR, GC, and more.

Backed by the highest quality accreditations for reference standards, including ISO 17034 and ISO 17025, our standards meet the highest expectations for accuracy, consistency, and regulatory compliance.

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Scale & Capability

Extensive and Growing Inventory

TLC offers over 24,000 certified reference standards available from stock, with approximately 2,000 new standards added each year.

Our portfolio includes drug impurities, nitrosamines, metabolite standards, stable isotope-labeled analogues, and amino acid and peptide drug standards—supporting a broad range of analytical, research, and regulatory applications.

Challenging Projects

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Each Quarter, Our Lab Tackles Some Of The Most Complex Challenges In Reference Standards Synthesis. Here's A Look At The Breakthroughs We've Achieved.

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Breakthrough

Breaking Boundaries in Complex Synthesis

TLC Successfully Produces N-Nitroso Ticagrelor, CAS No. 2476859-55-7

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Breakthrough

New Stable Isotope-Labeled Reference Standard: Minocycline-d6 Ditrifluoroacetate

We are pleased to announce the successful development of Minocycline-d6 Ditrifluoroacetate, a technically challenging stable isotope-labeled (SIL) reference standard.

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Breakthrough

New Stable Isotope-Labeled Reference Standard: Tacrolimus-13C-d2

We are pleased to announce the successful development of Tacrolimus-13C-d2, a high-quality stable isotope-labeled (SIL) reference standard designed to support demanding analytical and bioanalytical applications.

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Breakthrough

New Reference Standard: Retatrutide, TLC No. PR-178001, CAS# 2381089-83-2

We are pleased to announce the availability of Retatrutide (PR-178001), a high-quality peptide reference standard now available from stock to support analytical and research applications.

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Breakthrough

Neomycin Sulfate EP Impurity G

CAS#:54617-40-2;Synonyms:3-N-acetyl-2-deoxy-4-O-(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)-5-O-[3-O-(2,6-diamino-2,6-dideoxy-β-L-idopyranosyl)-β-D-ribofuranosyl]-D-streptamine

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Breakthrough

Triamcinolone-d5 (Triamcinolone Acetonide EP Impurity A-d5)

Synonyms:(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl-d2)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one-4,6,6-d3

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Breakthrough

Tranexamic Acid-15N-d2

Alternate CAS#:1197-18-8 (non-labelled) ; Synonyms:(1r,4r)-4-((amino-15N)methyl-d2)cyclohexane-1-carboxylic acid

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Breakthrough

Thiocolchicoside EP Impurity K (2-Hydroxy)

Synonyms:N-((S)-2-hydroxy-1-methoxy-10-(methylthio)-9-oxo-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide

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Breakthrough

Doxycycline EP Impurity D (4-epi-6-Epidoxycycline)

CAS#:97583-08-9 ; Synonyms:(4R,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

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Breakthrough

Spiramycin EP Impurity G Ditrifluoroacetate

Synonyms:(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-(((2S,3R,4S,5S,6R)-4-(dimethylamino)-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl) oxy)-10-(((2R,5S,6R)-5-(dimethylamino)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl) oxacyclohexadeca-11,13-dien-4-yl acetate, 2,2,2-trifluoroacetic acid (1:2)

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Impurity

Nitrosamine

Glucuronide

Stable Isotope Labeled (SIL)

Metabolite

API

Other

New Products

Our Latest Catalogues

Company News

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July 30

2025

TLC Named “Company of the Year – Canada 2025” by Pharma Tech Outlook Magazine

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Feburay 12

2026

New Reference Standard: Retatrutide, TLC No. PR-178001, CAS# 2381089-83-2

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January 01

2024

TLC is proud to share that we've secured ISO 17034 accreditation! This is a significant step in our unwavering dedication to quality and our promise to remain Your Trusted Source

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Advantages Of Working With TLC

Founded in 2007, TLC is a multi-national independent service company specializing in the custom synthesis of complex organic compounds used as Reference Standards by the biomedical and pharmaceutical communities worldwide.

Today, the global scientific community recognizes TLC as a trusted source for Reference Standards, offering unparalleled quality.

High Degree of scientific know-how

Complete COA provided for every compound

Highest quality standards & shortest delivery timelines

Licensed for controlled substances

Fully equipped synthesis and analytical facilities

Vast inventory of reference standards